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Gene Review

LTBR  -  lymphotoxin beta receptor (TNFR...

Homo sapiens

Synonyms: CD18, D12S370, LT-BETA-R, Lymphotoxin-beta receptor, TNF-R-III, ...
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Disease relevance of LTBR


High impact information on LTBR

  • Blockade of TNFSF14 signaling caused a substantial reduction in the expression of lymphotoxin beta receptor (LTbetaR)-controlled migration factors within the islets and disrupts organization of tertiary structures, leading to prevention of diabetes [6].
  • Recruitment and activation of naive T cells in the islets by lymphotoxin Beta receptor-dependent tertiary lymphoid structure [6].
  • This cytotoxicity is dependent on CD18 adhesive interactions but is independent of Fas/FasL [7].
  • The hyperproliferative, inflammatory skin disease in K14-Cre-IKK2fl/fl mice was a direct consequence of the presence of macrophages in the skin, as targeted deletion of CD18, which prevented accumulation of granulocytes but not macrophages, did not lead to major changes in the phenotype [8].
  • The CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling human psoriasis is characterized by reduced expression of the common chain of beta2 integrins (CD11/CD18) to only 2-16% of WT levels [9].

Biological context of LTBR


Anatomical context of LTBR


Associations of LTBR with chemical compounds


Physical interactions of LTBR


Regulatory relationships of LTBR


Other interactions of LTBR


Analytical, diagnostic and therapeutic context of LTBR


  1. Activation of the lymphotoxin beta receptor by cross-linking induces chemokine production and growth arrest in A375 melanoma cells. Degli-Esposti, M.A., Davis-Smith, T., Din, W.S., Smolak, P.J., Goodwin, R.G., Smith, C.A. J. Immunol. (1997) [Pubmed]
  2. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. Matsumoto, M., Hsieh, T.Y., Zhu, N., VanArsdale, T., Hwang, S.B., Jeng, K.S., Gorbalenya, A.E., Lo, S.Y., Ou, J.H., Ware, C.F., Lai, M.M. J. Virol. (1997) [Pubmed]
  3. Expression of three members of the TNF-R family of receptors (4-1BB, lymphotoxin-beta receptor, and Fas) in human lung. Boussaud, V., Soler, P., Moreau, J., Goodwin, R.G., Hance, A.J. Eur. Respir. J. (1998) [Pubmed]
  4. Muscle atrophy and bone loss after 90 days' bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study. Rittweger, J., Frost, H.M., Schiessl, H., Ohshima, H., Alkner, B., Tesch, P., Felsenberg, D. Bone (2005) [Pubmed]
  5. Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha. Marshall, W.L., Brinkman, B.M., Ambrose, C.M., Pesavento, P.A., Uglialoro, A.M., Teng, E., Finberg, R.W., Browning, J.L., Goldfeld, A.E. J. Immunol. (1999) [Pubmed]
  6. Recruitment and activation of naive T cells in the islets by lymphotoxin Beta receptor-dependent tertiary lymphoid structure. Lee, Y., Chin, R.K., Christiansen, P., Sun, Y., Tumanov, A.V., Wang, J., Chervonsky, A.V., Fu, Y.X. Immunity (2006) [Pubmed]
  7. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Grossman, W.J., Verbsky, J.W., Barchet, W., Colonna, M., Atkinson, J.P., Ley, T.J. Immunity (2004) [Pubmed]
  8. Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. Stratis, A., Pasparakis, M., Rupec, R.A., Markur, D., Hartmann, K., Scharffetter-Kochanek, K., Peters, T., van Rooijen, N., Krieg, T., Haase, I. J. Clin. Invest. (2006) [Pubmed]
  9. Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation. Wang, H., Peters, T., Kess, D., Sindrilaru, A., Oreshkova, T., Van Rooijen, N., Stratis, A., Renkl, A.C., Sunderkötter, C., Wlaschek, M., Haase, I., Scharffetter-Kochanek, K. J. Clin. Invest. (2006) [Pubmed]
  10. Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. VanArsdale, T.L., VanArsdale, S.L., Force, W.R., Walter, B.N., Mosialos, G., Kieff, E., Reed, J.C., Ware, C.F. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  11. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. Yu, K.Y., Kwon, B., Ni, J., Zhai, Y., Ebner, R., Kwon, B.S. J. Biol. Chem. (1999) [Pubmed]
  12. Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis. Kuai, J., Nickbarg, E., Wooters, J., Qiu, Y., Wang, J., Lin, L.L. J. Biol. Chem. (2003) [Pubmed]
  13. Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling. Li, C., Norris, P.S., Ni, C.Z., Havert, M.L., Chiong, E.M., Tran, B.R., Cabezas, E., Reed, J.C., Satterthwait, A.C., Ware, C.F., Ely, K.R. J. Biol. Chem. (2003) [Pubmed]
  14. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. Krajewska, M., Krajewski, S., Zapata, J.M., Van Arsdale, T., Gascoyne, R.D., Berern, K., McFadden, D., Shabaik, A., Hugh, J., Reynolds, A., Clevenger, C.V., Reed, J.C. Am. J. Pathol. (1998) [Pubmed]
  15. Priming by tumor necrosis factor-{alpha} of human neutrophil NADPH-oxidase activity induced by anti-proteinase-3 or anti-myeloperoxidase antibodies. Reumaux, D., Hordijk, P.L., Duthilleul, P., Roos, D. J. Leukoc. Biol. (2006) [Pubmed]
  16. Multiple sclerosis: expression of molecules of the tumor necrosis factor ligand and receptor families in relationship to the demyelinated plaque. Raine, C.S., Bonetti, B., Cannella, B. Rev. Neurol. (Paris) (1998) [Pubmed]
  17. GA-binding protein (GABP) and Sp1 are required, along with retinoid receptors, to mediate retinoic acid responsiveness of CD18 (beta 2 leukocyte integrin): a novel mechanism of transcriptional regulation in myeloid cells. Bush, T.S., St Coeur, M., Resendes, K.K., Rosmarin, A.G. Blood (2003) [Pubmed]
  18. Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation. Chang, Y.H., Hsieh, S.L., Chen, M.C., Lin, W.W. Exp. Cell Res. (2002) [Pubmed]
  19. Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells. Wu, M.Y., Hsu, T.L., Lin, W.W., Campbell, R.D., Hsieh, S.L. J. Biol. Chem. (1997) [Pubmed]
  20. Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid. Baens, M., Chaffanet, M., Cassiman, J.J., van den Berghe, H., Marynen, P. Genomics (1993) [Pubmed]
  21. Chemotactic factors stimulate CD18-dependent canine neutrophil adherence and motility on lung fibroblasts. Burns, A.R., Simon, S.I., Kukielka, G.L., Rowen, J.L., Lu, H., Mendoza, L.H., Brown, E.S., Entman, M.L., Smith, C.W. J. Immunol. (1996) [Pubmed]
  22. Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3. You, R.I., Chen, M.C., Wang, H.W., Chou, Y.C., Lin, C.H., Hsieh, S.L. Cancer Res. (2006) [Pubmed]
  23. Anti-inflammatory actions of lipoxin A(4) stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. Filep, J.G., Zouki, C., Petasis, N.A., Hachicha, M., Serhan, C.N. Blood (1999) [Pubmed]
  24. The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death. Chen, M.C., Hwang, M.J., Chou, Y.C., Chen, W.H., Cheng, G., Nakano, H., Luh, T.Y., Mai, S.C., Hsieh, S.L. J. Biol. Chem. (2003) [Pubmed]
  25. Sensitization of cells to TRAIL-induced apoptosis by decoy receptor 3. Wu, Y.Y., Chang, Y.C., Hsu, T.L., Hsieh, S.L., Lai, M.Z. J. Biol. Chem. (2004) [Pubmed]
  26. Lymphotoxin and LIGHT signaling pathways and target genes. Schneider, K., Potter, K.G., Ware, C.F. Immunol. Rev. (2004) [Pubmed]
  27. Relationship between interleukin-8 and neutrophil adhesion molecules in rheumatoid arthritis. De Gendt, C.M., De Clerck, L.S., Bridts, C.H., Van Osselaer, N., Stevens, W.J. Rheumatol. Int. (1996) [Pubmed]
  28. Interleukin-8 expression by human neutrophils activated by Helicobacter pylori soluble proteins. Kim, J.S., Jung, H.C., Kim, J.M., Song, I.S., Kim, C.Y. Scand. J. Gastroenterol. (1998) [Pubmed]
  29. Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor. Force, W.R., Cheung, T.C., Ware, C.F. J. Biol. Chem. (1997) [Pubmed]
  30. Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation. Chollet-Martin, S., Gatecel, C., Kermarrec, N., Gougerot-Pocidalo, M.A., Payen, D.M. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  31. Attenuation of cardiopulmonary bypass-derived inflammatory reactions reduces myocardial reperfusion injury in cardiac operations. Sawa, Y., Shimazaki, Y., Kadoba, K., Masai, T., Fukuda, H., Ohata, T., Taniguchi, K., Matsuda, H. J. Thorac. Cardiovasc. Surg. (1996) [Pubmed]
  32. Site of blood vessel damage and relevance of CD18 in a murine model of immune complex-mediated vasculitis. Sindrilaru, A., Seeliger, S., Ehrchen, J.M., Peters, T., Roth, J., Scharffetter-Kochanek, K., Sunderkötter, C.H. J. Invest. Dermatol. (2007) [Pubmed]
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