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Chemical Compound Review

AG-E-04536     1-[(1S,2R)-2- heptylcyclopentyl]octane

Synonyms: CHEBI:33023, HMDB04659, CTK0H8099, AC1L32WN, 8beta-prostane, ...
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Disease relevance of 8-Isoprostane


Psychiatry related information on 8-Isoprostane

  • We measured plasma 8-isoprostane levels in 157 healthy Japanese volunteers divided into three groups (64 non-habitual drinkers, 56 moderate drinkers and 37 habitual drinkers) according to their alcohol consumption per week [6].

High impact information on 8-Isoprostane


Chemical compound and disease context of 8-Isoprostane


Biological context of 8-Isoprostane


Anatomical context of 8-Isoprostane


Associations of 8-Isoprostane with other chemical compounds

  • High-salt intake for 4 weeks markedly elevated systolic arterial pressure, urinary excretion of protein, 8-isoprostane, and H(2)O(2), and the enzyme activity of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase along with the elevated expression of its subunits gp91phox and p47phox at the levels of mRNA and protein [24].
  • Urinary excretion of 8-isoprostane F2alpha (8-iso-PGF2alpha) was used as an index of whole-body lipid peroxidation [25].
  • In conclusion, cPLA2, PGE2, and ROS formation was activated by all particle types, whereas LTB4 production and 8-isoprostane were strongly dependent on particles' oxidative potential [26].
  • RESULTS: Compared with control subjects, exhaled LTE 4 ( P <.001), LTB 4 ( P <.001), and 8-isoprostane ( P <.001) levels were increased in both steroid-naive and steroid-treated atopic asthmatic children but not in atopic nonasthmatic children (LTE 4 , P=.14; LTB 4 , P=.23; and 8-isoprostane, P=.52) [27].
  • RESULTS: 8-Isoprostane, nitrogen oxides, and pH were significantly higher in EBC than in BAL (3.845 vs. 0.027 ng/ml, 28.4 vs. 3.8 muM, and 7.35 vs. 6.4, respectively; p < 0.001) [28].

Gene context of 8-Isoprostane


Analytical, diagnostic and therapeutic context of 8-Isoprostane


  1. 8-Isoprostane as a biomarker of oxidative stress in interstitial lung diseases. Montuschi, P., Ciabattoni, G., Paredi, P., Pantelidis, P., du Bois, R.M., Kharitonov, S.A., Barnes, P.J. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  2. 8-Isoprostane-induced endothelin-1 production by infant rat pulmonary artery smooth muscle cells is mediated by Rho-kinase. Yi, S.L., Kantores, C., Belcastro, R., Cabacungan, J., Tanswell, A.K., Jankov, R.P. Free Radic. Biol. Med. (2006) [Pubmed]
  3. Release of proinflammatory cytokines and 8-isoprostane from placenta, adipose tissue, and skeletal muscle from normal pregnant women and women with gestational diabetes mellitus. Lappas, M., Permezel, M., Rice, G.E. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  4. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. Montuschi, P., Kharitonov, S.A., Ciabattoni, G., Corradi, M., van Rensen, L., Geddes, D.M., Hodson, M.E., Barnes, P.J. Thorax (2000) [Pubmed]
  5. Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension. Adeagbo, A.S., Zhang, X., Patel, D., Joshua, I.G., Wang, Y., Sun, X., Igbo, I.N., Oriowo, M.A. J. Hypertens. (2005) [Pubmed]
  6. Improved method of plasma 8-Isoprostane measurement and association analyses with habitual drinking and smoking. Kitano, S., Hisatomi, H., Hibi, N., Kawano, K., Harada, S. World J. Gastroenterol. (2006) [Pubmed]
  7. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients. Schmielau, J., Finn, O.J. Cancer Res. (2001) [Pubmed]
  8. Enhancement of experimental colon cancer by genistein. Rao, C.V., Wang, C.X., Simi, B., Lubet, R., Kelloff, G., Steele, V., Reddy, B.S. Cancer Res. (1997) [Pubmed]
  9. Scavenger receptors: friend or foe in atherosclerosis? van Berkel, T.J., Out, R., Hoekstra, M., Kuiper, J., Biessen, E., van Eck, M. Curr. Opin. Lipidol. (2005) [Pubmed]
  10. Insulin resistance and type 2 diabetes in high-fat-fed mice are linked to high glycotoxin intake. Sandu, O., Song, K., Cai, W., Zheng, F., Uribarri, J., Vlassara, H. Diabetes (2005) [Pubmed]
  11. Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress. Beisswenger, P.J., Drummond, K.S., Nelson, R.G., Howell, S.K., Szwergold, B.S., Mauer, M. Diabetes (2005) [Pubmed]
  12. Oxidative stress and antioxidant status in fetal circulation in preeclampsia. Braekke, K., Harsem, N.K., Staff, A.C. Pediatr. Res. (2006) [Pubmed]
  13. Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis. Ogawa, F., Shimizu, K., Muroi, E., Hara, T., Hasegawa, M., Takehara, K., Sato, S. Rheumatology (Oxford, England) (2006) [Pubmed]
  14. Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia. Mehlhorn, U., Krahwinkel, A., Geissler, H.J., LaRosee, K., Fischer, U.M., Klass, O., Suedkamp, M., Hekmat, K., Tossios, P., Bloch, W. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  15. Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet. Rao, C.V., Simi, B., Hirose, Y., Upadhyaya, P., El-Bayoumy, K., Reddy, B.S. Int. J. Oncol. (2000) [Pubmed]
  16. Effect of valsartan, an angiotensin II receptor blocker, on markers of oxidation and glycation in Japanese type 2 diabetic subjects: Blood pressure-independent effect of valsartan. Saisho, Y., Komiya, N., Hirose, H. Diabetes Res. Clin. Pract. (2006) [Pubmed]
  17. Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury. Laffey, J.G., Jankov, R.P., Engelberts, D., Tanswell, A.K., Post, M., Lindsay, T., Mullen, J.B., Romaschin, A., Stephens, D., McKerlie, C., Kavanagh, B.P. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  18. Characterization of 8-epiprostaglandin F2alpha as a marker of amyloid beta-peptide-induced oxidative damage. Mark, R.J., Fuson, K.S., May, P.C. J. Neurochem. (1999) [Pubmed]
  19. Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis. Xi, H., Akishita, M., Nagai, K., Yu, W., Hasegawa, H., Eto, M., Kozaki, K., Toba, K. Atherosclerosis (2007) [Pubmed]
  20. Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat. Kantores, C., McNamara, P.J., Teixeira, L., Engelberts, D., Murthy, P., Kavanagh, B.P., Jankov, R.P. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  21. Induced sputum 8-isoprostane concentrations in inflammatory airway diseases. Wood, L.G., Garg, M.L., Simpson, J.L., Mori, T.A., Croft, K.D., Wark, P.A., Gibson, P.G. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  22. Peroxynitrite inhibits relaxation and induces pulmonary artery muscle contraction in the newborn rat. Belik, J., Jankov, R.P., Pan, J., Tanswell, A.K. Free Radic. Biol. Med. (2004) [Pubmed]
  23. 8-isoprostane increases expression of interleukin-8 in human macrophages through activation of mitogen-activated protein kinases. Scholz, H., Yndestad, A., Damås, J.K., Waehre, T., Tonstad, S., Aukrust, P., Halvorsen, B. Cardiovasc. Res. (2003) [Pubmed]
  24. Effects of thiol antioxidant on reduced nicotinamide adenine dinucleotide phosphate oxidase in hypertensive Dahl salt-sensitive rats. Zhang, L., Fujii, S., Igarashi, J., Kosaka, H. Free Radic. Biol. Med. (2004) [Pubmed]
  25. 8-Isoprostane F2alpha excretion is reduced in women by increased vegetable and fruit intake. Thompson, H.J., Heimendinger, J., Sedlacek, S., Haegele, A., Diker, A., O'Neill, C., Meinecke, B., Wolfe, P., Zhu, Z., Jiang, W. Am. J. Clin. Nutr. (2005) [Pubmed]
  26. Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles. Beck-Speier, I., Dayal, N., Karg, E., Maier, K.L., Schumann, G., Schulz, H., Semmler, M., Takenaka, S., Stettmaier, K., Bors, W., Ghio, A., Samet, J.M., Heyder, J. Free Radic. Biol. Med. (2005) [Pubmed]
  27. Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children. Mondino, C., Ciabattoni, G., Koch, P., Pistelli, R., Trové, A., Barnes, P.J., Montuschi, P. J. Allergy Clin. Immunol. (2004) [Pubmed]
  28. Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage. Jackson, A.S., Sandrini, A., Campbell, C., Chow, S., Thomas, P.S., Yates, D.H. Am. J. Respir. Crit. Care Med. (2007) [Pubmed]
  29. Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation. Carpagnano, G.E., Kharitonov, S.A., Foschino-Barbaro, M.P., Resta, O., Gramiccioni, E., Barnes, P.J. Thorax (2004) [Pubmed]
  30. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Akundi, R.S., Candelario-Jalil, E., Hess, S., Hüll, M., Lieb, K., Gebicke-Haerter, P.J., Fiebich, B.L. Glia (2005) [Pubmed]
  31. Macrophage lipoprotein lipase expression is increased in patients with heterozygous familial hypercholesterolemia. Beauchamp, M.C., Letendre, E., Renier, G. J. Lipid Res. (2002) [Pubmed]
  32. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide. Montuschi, P., Nightingale, J.A., Kharitonov, S.A., Barnes, P.J. Free Radic. Biol. Med. (2002) [Pubmed]
  33. N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro. Lappas, M., Permezel, M., Rice, G.E. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  34. Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Montuschi, P., Corradi, M., Ciabattoni, G., Nightingale, J., Kharitonov, S.A., Barnes, P.J. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  35. Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension. Zhou, L., Xiang, W., Potts, J., Floyd, M., Sharan, C., Yang, H., Ross, J., Nyanda, A.M., Guo, Z. Free Radic. Biol. Med. (2006) [Pubmed]
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