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Chemical Compound Review

Aerosporin     N-[3-amino-1-[[1-[[3-amino-1- [[6,9,18...

Synonyms: Poly-RX, Polimixina B, Polymyxine B, polymyxin b, AC1NWAPL, ...
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Disease relevance of SPBio_000359


High impact information on SPBio_000359

  • Selective bowel decontamination of recipients with polymyxin B sulfate would be a candidate for protection against early graft failure following OLT [1].
  • The effect of Abeta(25-35) on MCP-1 secretion was neither mimicked by a scrambled analogue nor affected by polymyxin B sulfate, even though the latter almost completely abolished the effect of LPS on MCP-1 expression [6].
  • In the presence of polymyxin B sulfate, the enhanced LF binding by LPS was abrogated [7].
  • MAF activity was not abolished by polymyxin B sulfate, suggesting that this activity is not mediated by or dependent on LPS [8].
  • A patient receiving polymyxin B sulfate intravenously for Gram-negative "anion gap". Both abnormalities resolved following discontinuation of the drug [9].

Chemical compound and disease context of SPBio_000359


Biological context of SPBio_000359


Anatomical context of SPBio_000359


Associations of SPBio_000359 with other chemical compounds


Gene context of SPBio_000359


Analytical, diagnostic and therapeutic context of SPBio_000359


  1. Selective bowel decontamination of recipients for prevention against liver injury following orthotopic liver transplantation: evaluation with rat models. Arai, M., Mochida, S., Ohno, A., Arai, S., Fujiwara, K. Hepatology (1998) [Pubmed]
  2. Infection prevention in severely myelosuppressed patients: a comparison between ciprofloxacin and a regimen of selective antibiotic modulation of the intestinal flora. Jansen, J., Cromer, M., Akard, L., Black, J.R., Wheat, L.J., Allen, S.D. Am. J. Med. (1994) [Pubmed]
  3. In-a-day electrochemical detection of coliforms in drinking water using a tyrosinase composite biosensor. Serra, B., Morales, M.D., Zhang, J., Reviejo, A.J., Hall, E.H., Pingarron, J.M. Anal. Chem. (2005) [Pubmed]
  4. Lipopolysaccharide interaction with rabbit erythrocyte membranes. Carr, C., Morrison, D.C. Infect. Immun. (1984) [Pubmed]
  5. Selective medium for Pseudomonas cepacia containing 9-chloro-9-(4-diethylaminophenyl)-10-phenylacridan and polymyxin B sulfate. Wu, B.J., Thompson, S.T. Appl. Environ. Microbiol. (1984) [Pubmed]
  6. Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells. Meda, L., Bernasconi, S., Bonaiuto, C., Sozzani, S., Zhou, D., Otvos, L., Mantovani, A., Rossi, F., Cassatella, M.A. J. Immunol. (1996) [Pubmed]
  7. Lactoferrin-lipopolysaccharide interactions. Effect on lactoferrin binding to monocyte/macrophage-differentiated HL-60 cells. Miyazawa, K., Mantel, C., Lu, L., Morrison, D.C., Broxmeyer, H.E. J. Immunol. (1991) [Pubmed]
  8. Identification and characterization of a human T cell line-derived lymphokine with MAF-like activity distinct from interferon-gamma. Lee, J.C., Rebar, L., Young, P., Ruscetti, F.W., Hanna, N., Poste, G. J. Immunol. (1986) [Pubmed]
  9. Hyperchloremia and negative anion gap associated with polymyxin B administration. O'Connor, D.T., Stone, R.A. Arch. Intern. Med. (1978) [Pubmed]
  10. Ultrastructural study of polymyxin-resistant isolates of Pseudomonas aeruginosa. Gilleland, H.E., Murray, R.G. J. Bacteriol. (1976) [Pubmed]
  11. Topically administered corticosteroids: effect on antibiotic-treated bacterial keratitis. Leibowitz, H.M., Kupferman, A. Arch. Ophthalmol. (1980) [Pubmed]
  12. Human conjunctivitis. II. Treatment. Leibowitz, H.M., Pratt, M.V., Flagstad, I.J., Berrospi, A.R., Kundsin, R. Arch. Ophthalmol. (1976) [Pubmed]
  13. A new antibiotic combination for frozen bovine semen 1. Control of mycoplasmas, ureaplasmas, Campylobacter fetus subsp. venerealis and Haemophilus somnus. Shin, S.J., Lein, D.H., Patten, V.H., Ruhnke, H.L. Theriogenology (1988) [Pubmed]
  14. Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Evans, M.E., Feola, D.J., Rapp, R.P. The Annals of pharmacotherapy. (1999) [Pubmed]
  15. Interferon-induced enhancement of macrophage-mediated tumor cytolysis and its difference from activation by lymphokines. Boraschi, D., Tagliabue, A. Eur. J. Immunol. (1981) [Pubmed]
  16. Effect of methylprednisolone and polymyxin B sulfate on endotoxin-induced inhibition of human neutrophil chemotaxis. Issekutz, A.C., Biggar, W.D. J. Lab. Clin. Med. (1978) [Pubmed]
  17. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study. Soroff, H.S., Sasvary, D.H. The Journal of burn care & rehabilitation. (1994) [Pubmed]
  18. Inhibition of the biologic effects of endotoxin on neutrophils by polymyxin B sulfate. Bannatyne, R.M., Harnett, N.M., Lee, K.Y., Biggar, W.D. J. Infect. Dis. (1977) [Pubmed]
  19. Gut-derived substances in activation of hepatic macrophages after partial hepatectomy in rats. Mochida, S., Ohta, Y., Ogata, I., Fujiwara, K. J. Hepatol. (1992) [Pubmed]
  20. Increased negativity of interstitial fluid pressure in rat trachea after mast cell degranulation. Koller, M.E., Woie, K., Reed, R.K. J. Appl. Physiol. (1993) [Pubmed]
  21. Seed extract of Aeginetia indica L induces cytokine production and lymphocyte proliferation in vitro. Chai, J.G., Bando, T., Nagasawa, H., Himeno, K., Sato, M., Ohkubo, S. Immunopharmacology (1994) [Pubmed]
  22. Antibiotic control of Campylobacter fetus by three extenders of bovine semen. Howard, T.H., Vasquez, L.A., Amann, R.P. J. Dairy Sci. (1982) [Pubmed]
  23. Effects of agars on determination of potency of polymyxin B sulfate by the agar plate diffusion method. Fujihara, M., Nishiyama, S., Hasegawa, S. Antimicrob. Agents Chemother. (1994) [Pubmed]
  24. Efficacy of diclofenac versus dexamethasone for treatment after strabismus surgery. Snir, M., Axer-Siegel, R., Friling, R., Weinberger, D. Ophthalmology (2000) [Pubmed]
  25. Effects of polymyxin B sulfate and polymyxin B nonapeptide on growth and permeability of the yeast Saccharomyces cerevisiae. Boguslawski, G. Mol. Gen. Genet. (1985) [Pubmed]
  26. Polymyxin B prevents increased sympathetic activity and alveolar macrophage tumor necrosis factor release in parenterally fed rats. Johnson, K.M., Garcia, R.M., Heitkemper, M., Helton, W.S. Archives of surgery (Chicago, Ill. : 1960) (1995) [Pubmed]
  27. Simultaneous determination of neomycin sulfate and polymyxin B sulfate by capillary electrophoresis with indirect UV detection. Srisom, P., Liawruangrath, B., Liawruangrath, S., Slater, J.M., Wangkarn, S. Journal of pharmaceutical and biomedical analysis (2007) [Pubmed]
  28. Inhibition of lipopolysaccharide-induced macrophage tumor necrosis factor-alpha synthesis by polymyxin B sulfate. Coyne, C.P., Fenwick, B.W. Am. J. Vet. Res. (1993) [Pubmed]
  29. The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. Mathur, J., Waldor, M.K. Infect. Immun. (2004) [Pubmed]
  30. Hydrolytic activities of human pancreatic phospholipase A2 and endotoxin-stimulated endogenous phospholipase A2 toward membrane phospholipids of erythrocytes. Nishijima, J., Okamoto, M., Yamano, T., Nakaguchi, K., Ogawa, M. J. Surg. Res. (1985) [Pubmed]
  31. Effect of polymyxin B on intestinal bacterial translocation in Pseudomonas aeruginosa wound-colonized burned mice. Dijkstra, H.M., Manson, W.L., Klasen, H.J., van der Waaij, D. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (1992) [Pubmed]
  32. A highly sensitive ELISA for the quantification of polymyxin B sulfate in human serum. Saita, T., Yoshida, M., Nakashima, M., Matsunaga, H., Fujito, H., Mori, M. Biol. Pharm. Bull. (1999) [Pubmed]
  33. Polymyxin B: pharmacokinetics of single doses given intravenously and intramuscularly to turkeys, and minimal inhibitory concentrations for Escherichia coli and Pasteurella multocida. Freidlin, P.J., Hoexter, S., Bock, R., Ziv, G., Samberg, Y., Risenberg, R., Inbar, A. Zentralblatt Veterinarmedizin Reihe B (1992) [Pubmed]
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