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Gene Review

BANK1  -  B-cell scaffold protein with ankyrin...

Homo sapiens

Synonyms: B-cell scaffold protein with ankyrin repeats, BANK, FLJ20706
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Disease relevance of BANK1

  • Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort [1].
  • The WHO, the United Nations Children's Fund (UNICEF), and the World Bank have recommended that 33 African countries at risk for yellow fever add the vaccine to the routine Expanded Programme on Immunization; studies show that this would be highly cost-effective [2].
  • World Bank reports on priorities for HIV and AIDS [3].
  • Duration of impaired consciousness in relation to side of lesion after severe head injury. NIH Traumatic Coma Data Bank Research Group [4].
  • BACKGROUND: In 1995, the World Bank launched an African Programme for Onchocerciasis Control to eliminate Onchocerca volvulus disease from 19 African countries by means of community-based ivermectin treatment (CBIT) [5].

Psychiatry related information on BANK1

  • In a prospective study of 1,805 hospitalized patients in the Stroke Data Bank of the National Institute of Neurological and Communicative Disorders and Stroke, the 1,273 with infarction were classified into diagnostic subtypes [6].
  • The study group is a part of 393 carriers found among 117 705 voluntary blood donors at the National Blood Bank, Hospital del Salvador, Santiago, Chile. None of the 38 carriers had a past history of illicit drug abuse, hepatitis, or work involving a high risk of hepatitis B virus infection [7].
  • We determined the prevalence of dementia in 927 patients with acute ischemic stroke aged greater than or equal to 60 years in the Stroke Data Bank cohort based on the examining neurologist's best judgment [8].
  • Two patients with the Kennedy's disease (KD) mutation have been identified in the Newcastle Brain Tissue Bank. One of these patients had presenile dementia as a prominent clinical feature, previously undescribed in KD [9].
  • OBJECTIVE: To compare the prevalence of obesity, household food consumption patterns, physical activity patterns and smoking between a rural and an urban community in the Palestinian West Bank and to describe the associations of the latter factors with body mass index (BMI) [10].

High impact information on BANK1

  • BACKGROUND AND METHODS: The Sydney Blood Bank Cohort consists of a blood donor and eight transfusion recipients who were infected before 1985 with a strain of human immunodeficiency virus type 1 (HIV-1) with a deletion in the region in which the nef gene and the long terminal repeat overlap [1].
  • World Bank meeting concludes drug resistance should not prevent distribution of antiretroviral therapy to poor countries [11].
  • Decreasing overflow from the Nordic seas into the Atlantic Ocean through the Faroe Bank channel since 1950 [12].
  • World Bank espouses public health for those in poverty [13].
  • Antitrypsin phenotypes were determined from 2,285 donors at the Barnes Hospital Blood Bank in St [14].

Chemical compound and disease context of BANK1


Biological context of BANK1

  • Transmembrane (TM) proteins constitute 15-30% of the genome, but <1% of the structures in the Protein Data Bank. This discrepancy is disturbing, and emphasizes that structure determination of TM proteins remains challenging [20].
  • The Protein Data Bank and the challenge of structural genomics [21].
  • By comparison, about half of the single domain proteins in the Protein Data Bank have their N- and C-terminal elements in contact, more than expected on a random probability basis but not nearly enough to account for the bias in protein folding [22].
  • Current knowledge about the determinants of beta-sheet formation has been notably improved by the structural and kinetic analysis of model peptides, by mutagenesis experiments in proteins and by the statistical analysis of the protein structure database (Protein Data Bank; PDB) [23].
  • The original model, using initial Glasgow Coma Scale score, hemorrhage size, and pulse pressure, accounted for mortality or survival at 30 days in 92% of patients in the Pilot Stroke Data Bank with a sensitivity of 0.84 and a specificity of 0.96 [24].

Anatomical context of BANK1

  • PATIENTS AND METHODS: Western blotting was performed on cytosols from frozen tumor specimens of 927 N- breast cancer patients in the San Antonio Breast Tumor Bank. The monoclonal antibody M1G8 was used to detect cathepsin D (in previous study, a polyclonal antiserum had been used) [25].
  • Due to the high rate of predicted carriers (> 63,000) in the Nebraska population (1990 U.S. Census = 1,578,358), we analyzed sperm DNA obtained from semen donors at the University of Nebraska Genetic Semen Bank for eight of the more common mutations to determine the frequency and diversity in our population [26].
  • We searched the Stroke Data Bank and personal files to find patients with CT-documented infarcts in the territory of the inferior division of the right middle cerebral artery [27].
  • These patients were classified as having strokes of determined origin or cryptogenic strokes according to criteria developed for the Stroke Data Bank of the National Institute of Neurological Disorders and Stroke. Separation of septum primum from secundum and the number of microbubbles appearing in left atrium were then quantitated [28].
  • Human stromal and endothelial cultures were established from corneas obtained from the Maryland Eye Bank. Cultures were incubated in the presence of human gamma interferon for 4 days, trypsinized, washed, and then stained with a monoclonal reagent specific for human Class II (HLA-DR) antigens [29].

Associations of BANK1 with chemical compounds

  • The finding that sigma is close to unity (1 +/- 0.2) indicates a noncooperative role for alanine in PII structure formation, consistent with statistical surveys of the Protein Data Bank that suggest that most PII structure occurs in isolated residues [30].
  • On a three-dimensional templated model of GLUT1 (Protein Data Bank code 1SUK), a molecular recognition program, AUTODOCK 3, reveals nine hexose-binding clusters spanning the entire "hydrophilic" channel [31].
  • Finally, we present a structural model for nicotinic acetylcholine receptor-alpha-cobratoxin interaction by superimposing the alpha-cobratoxin.alpha18-mer complex onto the crystal structure of the acetylcholine-binding protein (Protein Data Bank code ) [32].
  • The caddie protein, which consists of one six-strandedbeta-sheet and one alpha-helix, has no similarity with all proteins deposited into the Protein Data Bank. Although tyrosinase and catechol oxidase are classified into the type 3 copper protein family, the latter enzyme lacks monooxygenase activity [33].
  • Codon usage in 87 602 genes has been calculated using the nucleotide sequence data obtained from the GenBank Genetic Sequence Data Bank (Release 90.0; September 1995) [34].

Analytical, diagnostic and therapeutic context of BANK1

  • Serum samples from all cadaver organ donors to the New England Organ Bank between 1986 and 1990 were screened retrospectively for antibodies to HCV (anti-HCV) by enzyme-linked immunosorbent assay (ELISA) [35].
  • With the use of a specific radioimmunoassay, the concentration of CK-BB was measured in 524 sera (obtained from the National Cancer Institute-Mayo Clinic Serum Diagnostic Bank) from patients with a variety of benign and malignant disorders [36].
  • In 1983, 949 cases of acute non-fatal illness consisting of headache, dizziness, blurred vision, abdominal pain, myalgia, and fainting occurred in the West Bank. Physical examination and biochemical tests were otherwise normal [37].
  • A controlled study of hepatitis C transmission by organ transplantation. The New England Organ Bank Hepatitis C Study Group [38].
  • SETTING: Neurovascular Unit and Echocardiography Laboratory, Columbia-Presbyterian Medical Center, New York, New York. MEASUREMENTS: Patients were considered to have strokes of determined origin or cryptogenic strokes according to National Institute of Neurological Disorders and Stroke (NINDS) Stroke Data Bank criteria [39].


  1. Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort. Learmont, J.C., Geczy, A.F., Mills, J., Ashton, L.J., Raynes-Greenow, C.H., Garsia, R.J., Dyer, W.B., McIntyre, L., Oelrichs, R.B., Rhodes, D.I., Deacon, N.J., Sullivan, J.S. N. Engl. J. Med. (1999) [Pubmed]
  2. Yellow fever: a decade of reemergence. Robertson, S.E., Hull, B.P., Tomori, O., Bele, O., LeDuc, J.W., Esteves, K. JAMA (1996) [Pubmed]
  3. World Bank reports on priorities for HIV and AIDS. McGregor, A. Lancet (1997) [Pubmed]
  4. Duration of impaired consciousness in relation to side of lesion after severe head injury. NIH Traumatic Coma Data Bank Research Group. Levin, H.S., Gary, H.E., Eisenberg, H.M. Lancet (1989) [Pubmed]
  5. Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection. Gardon, J., Gardon-Wendel, N., Demanga-Ngangue, n.u.l.l., Kamgno, J., Chippaux, J.P., Boussinesq, M. Lancet (1997) [Pubmed]
  6. Infarcts of undetermined cause: the NINCDS Stroke Data Bank. Sacco, R.L., Ellenberg, J.H., Mohr, J.P., Tatemichi, T.K., Hier, D.B., Price, T.R., Wolf, P.A. Ann. Neurol. (1989) [Pubmed]
  7. Clinical and pathological study of asymptomatic HBsAg carriers in Chile. Velasco, M., González-Cerón, M., de la Fuente, C., Ruiz, A., Donoso, S., Katz, R. Gut (1978) [Pubmed]
  8. Dementia in stroke survivors in the Stroke Data Bank cohort. Prevalence, incidence, risk factors, and computed tomographic findings. Tatemichi, T.K., Foulkes, M.A., Mohr, J.P., Hewitt, J.R., Hier, D.B., Price, T.R., Wolf, P.A. Stroke (1990) [Pubmed]
  9. Kennedy's disease: unusual molecular pathologic and clinical features. Shaw, P.J., Thagesen, H., Tomkins, J., Slade, J.Y., Usher, P., Jackson, A., Curtis, A., Bushby, K., Ince, P.G. Neurology (1998) [Pubmed]
  10. Obesity in a rural and an urban Palestinian West Bank population. Abdul-Rahim, H.F., Holmboe-Ottesen, G., Stene, L.C., Husseini, A., Giacaman, R., Jervell, J., Bjertness, E. Int. J. Obes. Relat. Metab. Disord. (2003) [Pubmed]
  11. World Bank meeting concludes drug resistance should not prevent distribution of antiretroviral therapy to poor countries. Kuritzkes, D., Lange, J., Zewdie, D. Nat. Med. (2003) [Pubmed]
  12. Decreasing overflow from the Nordic seas into the Atlantic Ocean through the Faroe Bank channel since 1950. Hansen, B., Turrell, W.R., Østerhus, S. Nature (2001) [Pubmed]
  13. World Bank espouses public health for those in poverty. Greene, S. Nature (1993) [Pubmed]
  14. Antitrypsin phenotypes in St. Louis. Pierce, J.A., Eradio, B., Dew, T.A. JAMA (1975) [Pubmed]
  15. The metabolic syndrome in the West Bank population: an urban-rural comparison. Abdul-Rahim, H.F., Husseini, A., Bjertness, E., Giacaman, R., Gordon, N.H., Jervell, J. Diabetes Care (2001) [Pubmed]
  16. Quaternary organization of the Staphylothermus marinus phosphoenolpyruvate synthase: angular reconstitution from cryoelectron micrographs with molecular modeling. Li, W., Ottensmeyer, F.P., Harauz, G. J. Struct. Biol. (2000) [Pubmed]
  17. Epidemiology of visceral leishmaniasis in the Jenin District, West Bank: 1989-1998. Abdeen, Z.A., Sawalha, S.S., Eisenberger, C.L., Khanfar, H.M., Greenblatt, C.L., Yousef, O., Schnur, L.F., Azmi, K., Warburg, A., Bader, K.A., Jaffe, C.L., Baneth, G. Am. J. Trop. Med. Hyg. (2002) [Pubmed]
  18. Characterization of glycosylation and adherent properties of melanoma cell lines. Laidler, P., Lityńska, A., Hoja-Łukowicz, D., Łabedz, M., Przybyło, M., Ciołczyk-Wierzbicka, D., Pocheć, E., Trebacz, E., Kremser, E. Cancer Immunol. Immunother. (2006) [Pubmed]
  19. Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States). Dorgan, J.F., Sowell, A., Swanson, C.A., Potischman, N., Miller, R., Schussler, N., Stephenson, H.E. Cancer Causes Control (1998) [Pubmed]
  20. Transmembrane protein structures without X-rays. Fleishman, S.J., Unger, V.M., Ben-Tal, N. Trends Biochem. Sci. (2006) [Pubmed]
  21. The Protein Data Bank and the challenge of structural genomics. Berman, H.M., Bhat, T.N., Bourne, P.E., Feng, Z., Gilliland, G., Weissig, H., Westbrook, J. Nat. Struct. Biol. (2000) [Pubmed]
  22. The N-terminal to C-terminal motif in protein folding and function. Krishna, M.M., Englander, S.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  23. The design of linear peptides that fold as monomeric beta-sheet structures. Lacroix, E., Kortemme, T., Lopez de la Paz, M., Serrano, L. Curr. Opin. Struct. Biol. (1999) [Pubmed]
  24. Intracerebral hemorrhage: external validation and extension of a model for prediction of 30-day survival. Tuhrim, S., Dambrosia, J.M., Price, T.R., Mohr, J.P., Wolf, P.A., Hier, D.B., Kase, C.S. Ann. Neurol. (1991) [Pubmed]
  25. Cathepsin D by western blotting and immunohistochemistry: failure to confirm correlations with prognosis in node-negative breast cancer. Ravdin, P.M., Tandon, A.K., Allred, D.C., Clark, G.M., Fuqua, S.A., Hilsenbeck, S.H., Chamness, G.C., Osborne, C.K. J. Clin. Oncol. (1994) [Pubmed]
  26. Mutation analysis for cystic fibrosis to determine carrier status in 167 sperm donors from the Nebraska Genetic Semen Bank. Traystman, M.D., Schulte, N.A., MacDonald, M., Anderson, J.R., Sanger, W.G. Hum. Mutat. (1994) [Pubmed]
  27. Infarcts of the inferior division of the right middle cerebral artery: mirror image of Wernicke's aphasia. Caplan, L.R., Kelly, M., Kase, C.S., Hier, D.B., White, J.L., Tatemichi, T., Mohr, J., Price, T., Wolf, P. Neurology (1986) [Pubmed]
  28. Characteristics of patent foramen ovale associated with cryptogenic stroke. A biplane transesophageal echocardiographic study. Homma, S., Di Tullio, M.R., Sacco, R.L., Mihalatos, D., Li Mandri, G., Mohr, J.P. Stroke (1994) [Pubmed]
  29. Immunology of corneal allograft rejection: HLA-DR antigens on human corneal cells. Young, E., Stark, W.J., Prendergast, R.A. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  30. The polyproline II conformation in short alanine peptides is noncooperative. Chen, K., Liu, Z., Kallenbach, N.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  31. Docking studies show that D-glucose and quercetin slide through the transporter GLUT1. Cunningham, P., Afzal-Ahmed, I., Naftalin, R.J. J. Biol. Chem. (2006) [Pubmed]
  32. NMR-based binding screen and structural analysis of the complex formed between alpha-cobratoxin and an 18-mer cognate peptide derived from the alpha 1 subunit of the nicotinic acetylcholine receptor from Torpedo californica. Zeng, H., Hawrot, E. J. Biol. Chem. (2002) [Pubmed]
  33. Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis. Matoba, Y., Kumagai, T., Yamamoto, A., Yoshitsu, H., Sugiyama, M. J. Biol. Chem. (2006) [Pubmed]
  34. Codon usage tabulated from the international DNA sequence databases. Nakamura, Y., Wada, K., Wada, Y., Doi, H., Kanaya, S., Gojobori, T., Ikemura, T. Nucleic Acids Res. (1996) [Pubmed]
  35. Transmission of hepatitis C virus by organ transplantation. Pereira, B.J., Milford, E.L., Kirkman, R.L., Levey, A.S. N. Engl. J. Med. (1991) [Pubmed]
  36. Assessment of radioimmunoassay of serum creatine kinase BB (CK-BB) as a tumor marker: studies in patients with various cancers and a comparison of CK-BB concentrations to prostate acid phosphatase concentrations. Zweig, M.H., Van Steirteghem, A.C. J. Natl. Cancer Inst. (1981) [Pubmed]
  37. The Arjenyattah epidemic. Home interview data and toxicological aspects. Landrigan, P.J., Miller, B. Lancet (1983) [Pubmed]
  38. A controlled study of hepatitis C transmission by organ transplantation. The New England Organ Bank Hepatitis C Study Group. Pereira, B.J., Wright, T.L., Schmid, C.H., Levey, A.S. Lancet (1995) [Pubmed]
  39. Patent foramen ovale as a risk factor for cryptogenic stroke. Di Tullio, M., Sacco, R.L., Gopal, A., Mohr, J.P., Homma, S. Ann. Intern. Med. (1992) [Pubmed]
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